Clayton vacation rentals
We found 1,224 vacation rentals — enter your dates for availability
Discover a selection of vacation rentals in Clayton that are perfect for your trip. Whether you're going on vacation with family or friends, vacation homes have the amenities you expect for your stay, which might include WiFi and a hot tub. No matter what you're looking for, you're sure to find a rental that has what everyone needs, including a place that's non-smoking or offers accessibility.
Find the best place to stay - Clayton
The St. Charles Guest House, lovely historic home, fun for families and groups
Sleeps 8 · 3 bedrooms · 2 bathrooms
Find spaces that suit your style
Houses
Top rated rentals - Clayton
Photo gallery for BRAND NEW! Newly Furnished, Swanky Home with Great Location!
11/10 would stay again
- Peace of mindOur Book with Confidence guarantee gives you 24/7 support
- All the privacy of homeEnjoy full kitchens, laundry, pools, yards and more
- More for lessMore space, more privacy, more amenities — more value
Transportation options to and around Clayton
The nearest airport is in St. Louis Lambert Intl. Airport (STL), located 7.1 mi (11.4 km) from the city center. If you can't find a flight that's convenient for your trip, you could also fly into St. Louis, MO (SUS-Spirit of St. Louis), which is 15 mi (24.1 km) away.
Consider catching a ride on the metro at Clayton Station or Forsyth Station to more easily navigate the city.