I stayed recently rented this house for a group of my friends over from the UK. The house is really well set up with everything you'd need. As we were just there for 3 nights we spent most if it out by the pool and BBQ area - the separate kitchen/dining area is great for big groups.
We managed fine getting there by public transport from Madrid - busses run regularly (about hourly) and the house is about a mile from the centre of Lozoyuela. Lozoyuela has most of what you'd need - small supermarket (who will deliver to the house), several other shops and a few bars/cafes.
One of my friends is in a wheelchair and although the house isn't perfectly suited (there are some steps), we managed fine - two of the ground floor bedrooms and bathroom were fine for him.
In all we had a great weekend - all my friends we very impressed by the house and I'd certainly recommend it. All the communication and organisation with the owner was excellent.