A vacation rental in South America makes the perfect home away from home in this fascinating region, known for its fabulous beaches, natural wonders and unique cultural attractions.

In Brazil, the fifth largest country in the world, Rio de Janeiro apartments are ideal for experiencing this vibrant city. Guests of Rio de Janeiro vacation rentals can enjoy gorgeous sandy beaches like Copacabana and Ipanema Beach along with the locals, who are known for their minimalist bathing attire.

Attractions for vacationers who rent a Rio de Janeiro vacation rental include the classic Brazilian art at the Museu Nacional de Belas Artes, the Catedral de Sao Sebastao, the historical collections at the Museu Nacional, the Botanical Garden, and the world-famous Carnaval celebration.

Other highlights for guests of Brazil vacation rentals include bird watching in the Pantanal marsh and visiting magnificent Iguacu Falls and the Itaipu Dam, one of the world’s largest hydroelectric dams.

An Argentina vacation rental is ideal for enjoying this country’s sunny beaches and snow-capped mountains. Highlights for guests of Argentina apartments include experiencing the European-style capital city of Buenos Aires, with its fabulous shopping and cultural attractions, relaxing on a gorgeous beach at Mar del Plata or other beach resorts, and exploring the historic towns of Cordoba and Salta. Fabulous skiing can be found from June to October at Mount Cathedral near San Carlos de Bariloche, Las Leñas in Mendoza, La Hoya in Esquel, and many other locations.

The small country of Chile boasts an amazingly diverse landscape of beaches, mountains, deserts, geyers, forests and volcanoes. Highlights for guests of Chile vacation rentals include exploring the natural wonders of Villarrica National Park, sampling the cultural attractions of Santiago, and skiing at the Villarrica-Pucon Ski Center, El Colorado y Farallones, La Parva, and other resorts.

Guests of Peru vacation rentals can go trekking in the Andes, visit the spectacular Machu Picchu historical site, explore the country’s incredible biodiversity, and sunbathe on sunny beaches such as Paracas, south of Lima.

A Venezuela vacation rental makes a great base for enjoying beautiful beaches and exploring the many natural wonders in the country’s 62 national parks and preserves.

When you rent a Uruguay villa or vacation rental, you can bask on sunny beaches, enjoy a variety of water sports, golf on outstanding courses in the Punta Del Este area, and go horseback riding. Other popular South America accommodations include Bolivia and Colombia vacation rentals.

Read reviews of South America villas today to find the best place to stay for your vacation.

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South America: Apartments, Houses & More(28,500)

28,500 Results
  • 1 BR,
  • 1 BA,
  • Sleeps 4
(17)
$110
per night
5 night minimum stay
  • 1 BR,
  • 1 BA,
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1 - 6 night minimum stay
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  • Sleeps 10
(16)
$142 - $157
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3 - 5 night minimum stay
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3 - 5 night minimum stay
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$98 - $138
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  • 3 BA,
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2 - 7 night minimum stay
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$315 - $984
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  • 4 BA,
  • 1 HF BA,
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2 night minimum stay
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3 night minimum stay
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$118 - $197
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5 - 7 night minimum stay
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$315 - $590
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2 - 7 night minimum stay
(9)
$79 - $217
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  • 1 BR,
  • 1 BA,
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1 - 5 night minimum stay
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$787 - $2,755
per week
3 - 7 night minimum stay
  • 4 BR,
  • 4 BA,
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3 - 7 night minimum stay
(11)
  • 2 BR,
  • 2 BA,
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(11)
  • 2 BR,
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3 night minimum stay
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$157 - $394
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2 - 7 night minimum stay
  • 3 BR,
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$886 - $964
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  • 7 BR,
  • 7 BA,
  • 2 HF BA,
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$197
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  • 5 BA,
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  • 3 BR,
  • 2 BA,
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  • 1 BR,
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(33)
$354
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2 night minimum stay
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  • 4 BA,
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2 night minimum stay
(13)
$315 - $394
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3 - 6 night minimum stay
  • 5 BR,
  • 5 BA,
  • 1 HF BA,
  • Sleeps 15
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  • 1 BR,
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4 - 12 night minimum stay
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  • 2 BR,
  • 2 BA,
  • Sleeps 6
2 night minimum stay
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  • 1 BR,
  • 1 BA,
  • Sleeps 6
(23)
  • 1 BR,
  • 1 BA,
  • Sleeps 6
4 night minimum stay
(14)
$98
per night
3 - 4 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
3 - 4 night minimum stay
(9)
  • 1 BR,
  • 1 BA,
  • Sleeps 4
5 night minimum stay
(20)