A Florida Lower Keys vacation rental makes a great home away from home in the Florida Keys.

Key West, the southernmost town in the U.S., offers the ultimate laid-back Florida Keys vacation. Key West's palm-lined streets are lined with quaint cottages, lush gardens, sidewalk cafes, open-air bars and funky shops. Guests of Key West vacation rentals can join in the fund each evening as a crowd gathers at Mallory Dock for an impromptu celebration of the spectacular sunset. Other attractions for guests of Key West vacation rentals including snorkeling, diving, fishing and visiting Ernest Hemingway’s home and the John Audubon House.

Other activities in Florida's Lower Keys include basking on the beautiful white sand beach at Bahia Hondo State Park, snorkeling or diving on the Looe Key coral reef, or spotting the tiny Key Deer at National Key Deer Refuge.

Veterans Memorial Park, on Little Duck Key at mile marker 40, is a pet- and family-friendly destination.

Don’t miss out on other great cities. Consider Cudjoe Key rentals or Big Pine Key Vacation Rentals. You're sure to find the perfect Florida Lower Keys vacation rental for a memorable Florida vacation. Reserve your Lower Keys Florida vacation rental now for best selection!

Expand your search for Florida vacation rentals to include Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, or Orlando vacation home rentals near Disney.

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Lower Florida Keys: Houses, Condos & More(1,254)

1,254 Results
2 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 5
#411266
(63)
7 night minimum stay
  • 2 BR,
  • 1 BA,
  • Sleeps 4
#261681
(29)
7 night minimum stay
  • 2 BR,
  • 1 BA,
  • Sleeps 4
#244472
(62)
7 night minimum stay
  • 1 BR,
  • 1 BA,
  • Sleeps 2
#290407
(41)
30 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 6
#277391
(35)
3 - 4 night minimum stay
  • 3 BR,
  • 3 BA,
  • Sleeps 10
#367100
(15)
7 night minimum stay
  • 2 BR,
  • 1 BA,
  • Sleeps 4
#938538
(29)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 5
#982960
(19)
3 - 5 night minimum stay
  • 1 BR,
  • 1 BA,
  • Sleeps 2
#972748
(22)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 4
#420695vb
(37)
3 - 5 night minimum stay
  • 1 BR,
  • 1 BA,
  • Sleeps 4
#3472045
(22)
3 - 6 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 6
#959155
(15)
7 night minimum stay
  • 3 BR,
  • 3 BA,
  • Sleeps 8
#436601vb
(8)
7 night minimum stay
  • 2 BR,
  • 1 BA,
  • Sleeps 6
#3539485
(8)
4 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 8
#135603
(64)
3 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
#499539vb
(7)
28 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
#3498085
(6)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
#390190
(17)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
#390213
(25)
4 night minimum stay
  • 2 BR,
  • 3 BA,
  • Sleeps 6
#904144
(48)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
#904145
(35)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
#390177
(16)
7 night minimum stay
  • 2 BR,
  • 1 BA,
  • 1 HF BA,
  • Sleeps 6
#390205
(12)
7 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 10
#317093
(59)
7 night minimum stay
  • 5 BR,
  • 3 BA,
  • 1 HF BA,
  • Sleeps 8
#996261
(18)
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
#315267
(52)
3 - 7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 8
#929000
(6)
3 - 5 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
#557096vb
(6)
3 - 6 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 10
#903627
(20)