Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast: Condos, Houses & More(9,471)

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Private Access to the Beach & 1 Block to the Village
    3 Bedrooms,
  • 2 Bathrooms, 
  • 1 Half Bath
    • , Sleeps 10
$182
per night

Private Access to the Beach & 1 Block to the Village

Book it Now!
2 - 7 night Minimum Stay
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 10
  1. Florida South Central Gulf Coast >
  2. Siesta Key Villa
#228042
    (20)
    True Beachfront Beach House on Private Beach
      2 Bedrooms, Sleeps 4
    $1,204 - $1,820
    per week

    True Beachfront Beach House on Private Beach

    Book it Now!
    7 night Minimum Stay
    • 2 BR,
    • Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Manasota Key House
    #308815
      (37)
      Exclusive Waterfront Villa Tropical Breeze, Pool + Spa, WIFI, TIKI Hut, 2 Jetski
        4 Bedrooms,
      • 2 Bathrooms
        • , Sleeps 8
      $128 - $157
      per night

      Exclusive Waterfront Villa Tropical Breeze, Pool + Spa, WIFI, TIKI Hut, 2 Jetski

      Book it Now!
      5 night Minimum Stay
      • 4 BR,
      • 2 BA,
      • Sleeps 8
      1. Florida South Central Gulf Coast >
      2. Cape Coral Villa
      #518306
        (46)
        SIESTA KEY - 2BR 2BA - Sorry, July is Gone Next Avail is August
          2 Bedrooms,
        • 2 Bathrooms
          • , Sleeps 4
        $865 - $1,275
        per week

        SIESTA KEY - 2BR 2BA - Sorry, July is Gone Next Avail is August

        7 night Minimum Stay
        • 2 BR,
        • 2 BA,
        • Sleeps 4
        1. Florida South Central Gulf Coast >
        2. Siesta Key Condo
        #294616
          (45)
          Luxury Remodeled Beachfront Penthouse with Private Sundeck
            2 Bedrooms,
          • 2 Bathrooms
            • , Sleeps 6
          $1,904 - $3,885
          per week

          Luxury Remodeled Beachfront Penthouse with Private Sundeck

          Book it Now!
          7 night Minimum Stay
          • 2 BR,
          • 2 BA,
          • Sleeps 6
          1. Florida South Central Gulf Coast >
          2. Sanibel Island Condo
          #165420vb
            (9)
            Contemporary Pool Villa - private Beach - heated Pool and Jacuzzi - WiFi!
              3 Bedrooms,
            • 2 Bathrooms
              • , Sleeps 7
            $745 - $1,245
            per week

            Contemporary Pool Villa - private Beach - heated Pool and Jacuzzi - WiFi!

            7 - 28 night Minimum Stay
            • 3 BR,
            • 2 BA,
            • Sleeps 7
            1. Florida South Central Gulf Coast >
            2. Venice House
            #788891
              (14)
              Beachfront Penthouse - Gulf View! 2 BR/BA, WiFi, #1 Beach in the US!
                2 Bedrooms,
              • 2 Bathrooms
                • , Sleeps 6
              $999 - $1,750
              per week

              Beachfront Penthouse - Gulf View! 2 BR/BA, WiFi, #1 Beach in the US!

              Book it Now!
              7 night Minimum Stay
              • 2 BR,
              • 2 BA,
              • Sleeps 6
              1. Florida South Central Gulf Coast >
              2. Siesta Key Condo
              #387889vb
                (11)
                One of the Nicest Homes on Captiva Island!
                  3 Bedrooms,
                • 2 Bathrooms
                  • , Sleeps 6
                $1,595 - $3,695
                per week

                One of the Nicest Homes on Captiva Island!

                7 night Minimum Stay
                • 3 BR,
                • 2 BA,
                • Sleeps 6
                1. Florida South Central Gulf Coast >
                2. Captiva Island House
                #200223
                  (115)
                  Villa of highest class in southern location, big pool area, direct golf access
                    4 Bedrooms,
                  • 3 Bathrooms
                    • , Sleeps 10
                  $164 - $182
                  per night

                  Villa of highest class in southern location, big pool area, direct golf access

                  Book it Now!
                  3 night Minimum Stay
                  • 4 BR,
                  • 3 BA,
                  • Sleeps 10
                  1. Florida South Central Gulf Coast >
                  2. Cape Coral Villa
                  #43344
                    (17)
                    Directly on Siesta Key Beach, 2 Blocks to Village, Ground Floor
                      2 Bedrooms,
                    • 2 Bathrooms
                      • , Sleeps 5
                    $805 - $1,995
                    per week

                    Directly on Siesta Key Beach, 2 Blocks to Village, Ground Floor

                    Book it Now!
                    7 night Minimum Stay
                    • 2 BR,
                    • 2 BA,
                    • Sleeps 5
                    1. Florida South Central Gulf Coast >
                    2. Siesta Key Condo
                    #3024960
                      (8)
                      Turtle Bay Condos * Lemon Bay * Beach * Heated Pool * Boat Dock * Fishing * WiFi
                        2 Bedrooms,
                      • 1 Bathroom
                        • , Sleeps 6
                      $150 - $225
                      per night

                      Turtle Bay Condos * Lemon Bay * Beach * Heated Pool * Boat Dock * Fishing * WiFi

                      2 night Minimum Stay
                      • 2 BR,
                      • 1 BA,
                      • Sleeps 6
                      1. Florida South Central Gulf Coast >
                      2. Manasota Key Condo
                      #182250
                        (70)
                        Elegant Beachfront Condo w/pool ! Avail. May 19th - May 25th
                          3 Bedrooms,
                        • 2 Bathrooms
                          • , Sleeps 8
                        $1,900 - $2,800
                        per week

                        Elegant Beachfront Condo w/pool ! Avail. May 19th - May 25th

                        7 night Minimum Stay
                        • 3 BR,
                        • 2 BA,
                        • Sleeps 8
                        1. Anna Maria Island >
                        2. Bradenton Beach Condo
                        #361357
                          (19)
                          Beautiful Luxury Private Waterside Pool Villa in quiet location. Boat access.
                            4 Bedrooms,
                          • 3 Bathrooms
                            • , Sleeps 8
                          $840 - $1,225
                          per week

                          Beautiful Luxury Private Waterside Pool Villa in quiet location. Boat access.

                          7 night Minimum Stay
                          • 4 BR,
                          • 3 BA,
                          • Sleeps 8
                          1. Florida South Central Gulf Coast >
                          2. Cape Coral Villa
                          #348923
                            (42)
                            Special Offer 15% off Special Offer on open weeks 2013 (June 1 - December 8)
                            Villa with 200 m2 w/pool on freshwater canal and golf course in central location
                              4 Bedrooms,
                            • 3 Bathrooms
                              • , Sleeps 8
                            $120 - $173
                            per night

                            Villa with 200 m2 w/pool on freshwater canal and golf course in central location

                            4 - 7 night Minimum Stay
                            • 4 BR,
                            • 3 BA,
                            • Sleeps 8
                            1. Florida South Central Gulf Coast >
                            2. Cape Coral Villa
                            #776602
                              (15)
                              Beautifully Decorated with Great Views and Pool
                                2 Bedrooms,
                              • 2 Bathrooms, 
                              • 1 Half Bath
                                • , Sleeps 7
                              $833
                              per week

                              Beautifully Decorated with Great Views and Pool

                              Book it Now!
                              7 - 31 night Minimum Stay
                              • 2 BR,
                              • 2 BA,
                              • 1 HF BA,
                              • Sleeps 7
                              1. Anna Maria Island >
                              2. Holmes Beach Condo
                              #187770vb
                                (6)
                                Nightly (4night Min) Rental At Lovely Sanibel Cottage with Short Walk To Beach
                                  2 Bedrooms, Sleeps 4
                                $164 - $314
                                per night

                                Nightly (4night Min) Rental At Lovely Sanibel Cottage with Short Walk To Beach

                                Book it Now!
                                4 - 6 night Minimum Stay
                                • 2 BR,
                                • Sleeps 4
                                1. Florida South Central Gulf Coast >
                                2. Sanibel Island House
                                #455899vb
                                  (6)
                                  Remodeled 3 BR Pool Waterfront Dock !
                                    3 Bedrooms,
                                  • 2 Bathrooms
                                    • , Sleeps 8
                                  $125 - $159
                                  per night

                                  Remodeled 3 BR Pool Waterfront Dock !

                                  Book it Now!
                                  4 night Minimum Stay
                                  • 3 BR,
                                  • 2 BA,
                                  • Sleeps 8
                                  1. Florida South Central Gulf Coast >
                                  2. Port Charlotte House
                                  #392639vb
                                    (5)
                                    Yacht Club- Direct Access, Private Pool, Wifi
                                      3 Bedrooms,
                                    • 2 Bathrooms
                                      • , Sleeps 8
                                    $595 - $847
                                    per week

                                    Yacht Club- Direct Access, Private Pool, Wifi

                                    Book it Now!
                                    7 night Minimum Stay
                                    • 3 BR,
                                    • 2 BA,
                                    • Sleeps 8
                                    1. Florida South Central Gulf Coast >
                                    2. Cape Coral House
                                    #404023vb
                                      (5)
                                      25 Steps to sand GULF FRONT CONDO Private, Quiet, 1st floor
                                        2 Bedrooms,
                                      • 2 Bathrooms
                                        • , Sleeps 4
                                      $1,400 - $1,750
                                      per week

                                      25 Steps to sand GULF FRONT CONDO Private, Quiet, 1st floor

                                      Book it Now!
                                      7 night Minimum Stay
                                      • 2 BR,
                                      • 2 BA,
                                      • Sleeps 4
                                      1. Anna Maria Island >
                                      2. Holmes Beach Condo
                                      #307642
                                        (4)
                                        Waterfront,Eletric Heated Pool,Wifi,over 2100 sq ft
                                          3 Bedrooms,
                                        • 2 Bathrooms
                                          • , Sleeps 6
                                        $688 - $889
                                        per week

                                        Waterfront,Eletric Heated Pool,Wifi,over 2100 sq ft

                                        Book it Now!
                                        7 night Minimum Stay
                                        • 3 BR,
                                        • 2 BA,
                                        • Sleeps 6
                                        1. Florida South Central Gulf Coast >
                                        2. Cape Coral Villa
                                        #3471265
                                          (5)
                                          New Luxury home, pool, 600ft from sandy gulf beach
                                            3 Bedrooms,
                                          • 2 Bathrooms, 
                                          • 1 Half Bath
                                            • , Sleeps 8
                                          $1,610 - $2,450
                                          per week

                                          New Luxury home, pool, 600ft from sandy gulf beach

                                          7 night Minimum Stay
                                          • 3 BR,
                                          • 2 BA,
                                          • 1 HF BA,
                                          • Sleeps 8
                                          1. Anna Maria Island >
                                          2. Holmes Beach House
                                          #179538
                                            (10)
                                            May 27-June 2 available for $1,100.00
                                              3 Bedrooms,
                                            • 2 Bathrooms, 
                                            • 1 Half Bath
                                              • , Sleeps 10

                                            May 27-June 2 available for $1,100.00

                                            • 3 BR,
                                            • 2 BA,
                                            • 1 HF BA,
                                            • Sleeps 10
                                            1. Florida South Central Gulf Coast >
                                            2. Siesta Key Condo
                                            #382819vb
                                              (24)
                                              Walk to the Beach - Vintage Charm Bungalow on Longboat Key
                                                3 Bedrooms,
                                              • 2 Bathrooms
                                                • , Sleeps 6
                                              $185 - $200
                                              per night

                                              Walk to the Beach - Vintage Charm Bungalow on Longboat Key

                                              Book it Now!
                                              3 - 4 night Minimum Stay
                                              • 3 BR,
                                              • 2 BA,
                                              • Sleeps 6
                                              1. Florida South Central Gulf Coast >
                                              2. Longboat Key House
                                              #414104vb
                                                (4)
                                                Luxury 2 BR/2 BA- 1st Fl Wifi/HDTV - Hurry book your fall vacation!
                                                  2 Bedrooms,
                                                • 2 Bathrooms
                                                  • , Sleeps 5
                                                $568 - $1,050
                                                per week

                                                Luxury 2 BR/2 BA- 1st Fl Wifi/HDTV - Hurry book your fall vacation!

                                                7 night Minimum Stay
                                                • 2 BR,
                                                • 2 BA,
                                                • Sleeps 5
                                                1. Florida South Central Gulf Coast >
                                                2. Siesta Key Condo
                                                #31037vb
                                                  (21)
                                                  Clean Spacious 2 BR Condo at Siesta Beach - Walk to Village!
                                                    2 Bedrooms, Sleeps 6
                                                  $860 - $1,464
                                                  per week

                                                  Clean Spacious 2 BR Condo at Siesta Beach - Walk to Village!

                                                  7 night Minimum Stay
                                                  • 2 BR,
                                                  • Sleeps 6
                                                  1. Florida South Central Gulf Coast >
                                                  2. Siesta Key Condo
                                                  #970874
                                                    (13)
                                                    All new Waterfront Condo, Wifi, HDTV, Pool, Tennis, Fishing Pier
                                                      2 Bedrooms,
                                                    • 2 Bathrooms
                                                      • , Sleeps 4
                                                    $130
                                                    per night

                                                    All new Waterfront Condo, Wifi, HDTV, Pool, Tennis, Fishing Pier

                                                    Book it Now!
                                                    1 - 7 night Minimum Stay
                                                    • 2 BR,
                                                    • 2 BA,
                                                    • Sleeps 4
                                                    1. Florida South Central Gulf Coast >
                                                    2. Sanibel Island Condo
                                                    #434717vb
                                                      (4)
                                                      Luxurious Direct Beachfront Condo **Aug 10-17, Aug 24 Onward Avail**
                                                        3 Bedrooms,
                                                      • 2 Bathrooms
                                                        • , Sleeps 8
                                                      $300
                                                      per night

                                                      Luxurious Direct Beachfront Condo **Aug 10-17, Aug 24 Onward Avail**

                                                      4 - 7 night Minimum Stay
                                                      • 3 BR,
                                                      • 2 BA,
                                                      • Sleeps 8
                                                      1. Anna Maria Island >
                                                      2. Bradenton Beach Condo
                                                      #240776
                                                        (113)
                                                        Villa Ultima, Ultimate Location, 3 Minute Walk to Cape Harbour Marina
                                                          4 Bedrooms,
                                                        • 4 Bathrooms
                                                          • , Sleeps 11
                                                        $1,750
                                                        per week

                                                        Villa Ultima, Ultimate Location, 3 Minute Walk to Cape Harbour Marina

                                                        7 night Minimum Stay
                                                        • 4 BR,
                                                        • 4 BA,
                                                        • Sleeps 11
                                                        1. Florida South Central Gulf Coast >
                                                        2. Cape Coral Villa
                                                        #14834vb
                                                          (17)
                                                          Fine Living Relaxation and Enjoyment! Enjoy Pool, Beach and Sunsets
                                                            3 Bedrooms,
                                                          • 2 Bathrooms, 
                                                          • 1 Half Bath
                                                            • , Sleeps 12
                                                          $286 - $400
                                                          per night

                                                          Fine Living Relaxation and Enjoyment! Enjoy Pool, Beach and Sunsets

                                                          Book it Now!
                                                          3 - 5 night Minimum Stay
                                                          • 3 BR,
                                                          • 2 BA,
                                                          • 1 HF BA,
                                                          • Sleeps 12
                                                          1. Florida South Central Gulf Coast >
                                                          2. Longboat Key House
                                                          #447571vb
                                                            (4)
                                                            Beachfront! Spectacular Sunset Dining! 8/17-8/24 Last week at $3,000 Special!
                                                              4 Bedrooms,
                                                            • 4 Bathrooms
                                                              • , Sleeps 11
                                                            $3,003 - $7,504
                                                            per week

                                                            Beachfront! Spectacular Sunset Dining! 8/17-8/24 Last week at $3,000 Special!

                                                            7 night Minimum Stay
                                                            • 4 BR,
                                                            • 4 BA,
                                                            • Sleeps 11
                                                            1. Florida South Central Gulf Coast >
                                                            2. Captiva Island House
                                                            #92300vb
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