Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast: Houses, Condos & More(11,792)

11,792 Results
$1,995 - $3,995
per week
7 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 8
7 night minimum stay
(17)
$1,045 - $2,200
per week
7 - 28 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
7 - 28 night minimum stay
(25)
  • 2 BR,
  • 1 BA,
  • Sleeps 4
2 - 7 night minimum stay
(38)
$229 - $255
per night
4 - 7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 5
4 - 7 night minimum stay
(56)
$229 - $255
per night
4 - 7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 5
4 - 7 night minimum stay
(56)
  • 2 BR,
  • 2 BA,
  • Sleeps 6
3 - 7 night minimum stay
(27)
  • 2 BR,
  • 2 BA,
  • Sleeps 8
3 - 7 night minimum stay
(31)
$1,225 - $2,275
per week
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
7 night minimum stay
(16)
$1,400 - $3,000
per week
7 night minimum stay
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 8
7 night minimum stay
(5)
  • 3 BR,
  • 2 BA,
  • Sleeps 8
5 night minimum stay
(50)
  • 3 BR,
  • 2 BA,
  • Sleeps 8
3 night minimum stay
(25)
  • 2 BR,
  • 2 BA,
  • Sleeps 6
7 night minimum stay
(8)
  • 4 BR,
  • 3 BA,
  • Sleeps 10
3 - 7 night minimum stay
(18)
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
7 night minimum stay
(11)
  • 4 BR,
  • 3 BA,
  • Sleeps 8
2 - 7 night minimum stay
(26)
$1,325 - $2,399
per week
4 - 7 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 8
4 - 7 night minimum stay
(22)
$688 - $889
per week
7 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 6
7 night minimum stay
(19)
$300 - $400
per night
3 - 7 night minimum stay
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 10
3 - 7 night minimum stay
(15)
$700 - $1,225
per week
7 - 28 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 8
7 - 28 night minimum stay
(17)
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
4 night minimum stay
(22)
$1,800 - $2,600
per week
7 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 4
7 night minimum stay
(11)
$1,650 - $1,950
per week
7 night minimum stay
  • 3 BR,
  • 3 BA,
  • Sleeps 6
7 night minimum stay
(28)
$450 - $700
per night
4 - 6 night minimum stay
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 6
4 - 6 night minimum stay
(17)
$1,545 - $2,350
per week
7 - 14 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
7 - 14 night minimum stay
(14)
$284 - $325
per night
4 - 7 night minimum stay
  • 2 BR,
  • 3 BA,
  • Sleeps 6
4 - 7 night minimum stay
(18)
$284 - $325
per night
4 - 7 night minimum stay
  • 2 BR,
  • 3 BA,
  • Sleeps 6
4 - 7 night minimum stay
(18)
$1,475 - $2,870
per week
7 night minimum stay
  • 4 BR,
  • 2 BA,
  • Sleeps 11
7 night minimum stay
(18)
$170 - $350
per night
1 - 5 night minimum stay
  • 2 BR,
  • 2 BA,
  • Sleeps 6
1 - 5 night minimum stay
(49)