Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast: Condos, Houses & More(10,493)

10,493 Results
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7 night minimum stay
  • 3 BR,
  • 2 BA,
  • Sleeps 6
    (46)
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    7 night minimum stay
    • 2 BR,
    • 2 BA,
    • Sleeps 6
      (17)
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      7 night minimum stay
      • 2 BR,
      • 2 BA,
      • Sleeps 6
        (17)
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        7 - 28 night minimum stay
        • 2 BR,
        • 1 BA,
        • Sleeps 4
          (35)
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          7 night minimum stay
          • 4 BR,
          • 3 BA,
          • 1 HF BA,
          • Sleeps 8
            (31)
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            2 - 7 night minimum stay
            • 3 BR,
            • 2 BA,
            • 1 HF BA,
            • Sleeps 10
              (28)
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              5 - 7 night minimum stay
              • 2 BR,
              • 2 BA,
              • Sleeps 6
                (63)
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                4 night minimum stay
                • 3 BR,
                • 3 BA,
                • Sleeps 8
                  (12)
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                  7 - 14 night minimum stay
                  • 3 BR,
                  • 2 BA,
                  • Sleeps 6
                    (38)
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                    7 night minimum stay
                    • 3 BR,
                    • 2 BA,
                    • Sleeps 8
                      (21)
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                      7 - 14 night minimum stay
                      • 2 BR,
                      • 2 BA,
                      • Sleeps 6
                        (39)
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                        7 night minimum stay
                        • 4 BR,
                        • 2 BA,
                        • 1 HF BA,
                        • Sleeps 12
                          (35)
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                          7 - 14 night minimum stay
                          • 2 BR,
                          • 2 BA,
                          • Sleeps 6
                            (47)
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                            7 night minimum stay
                            • 3 BR,
                            • 3 BA,
                            • Sleeps 10
                              (18)
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                              7 night minimum stay
                              • 2 BR,
                              • 2 BA,
                              • Sleeps 4
                                (20)
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                                3 - 7 night minimum stay
                                • 2 BR,
                                • 2 BA,
                                • Sleeps 6
                                  (14)
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                                  7 night minimum stay
                                  • 4 BR,
                                  • 3 BA,
                                  • Sleeps 8
                                    (57)
                                    $895 - $1,795
                                    per week
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                                    7 night minimum stay
                                    • 2 BR,
                                    • 2 BA,
                                    • Sleeps 4
                                      (35)
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                                      7 night minimum stay
                                      • 4 BR,
                                      • 3 BA,
                                      • Sleeps 8
                                        (34)
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                                        7 night minimum stay
                                        • 2 BR,
                                        • 2 BA,
                                        • Sleeps 6
                                          (9)
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                                          7 night minimum stay
                                          • 3 BR,
                                          • 2 BA,
                                          • Sleeps 6
                                            (13)
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                                            7 night minimum stay
                                            • 3 BR,
                                            • 2 BA,
                                            • Sleeps 6
                                              (27)
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                                              7 - 30 night minimum stay
                                              • 3 BR,
                                              • 2 BA,
                                              • Sleeps 6
                                                (20)
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                                                5 night minimum stay
                                                • 3 BR,
                                                • 2 BA,
                                                • Sleeps 8
                                                  (45)
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                                                  7 night minimum stay
                                                  • 3 BR,
                                                  • 3 BA,
                                                  • Sleeps 10
                                                    (18)
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                                                    7 night minimum stay
                                                    • 4 BR,
                                                    • 3 BA,
                                                    • Sleeps 8
                                                      (35)
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                                                      7 night minimum stay
                                                      • 1 BR,
                                                      • 1 BA,
                                                      • Sleeps 4
                                                        (19)