Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast Rentals: Condos, Villa, Homes & More(4,510)

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HomeAway Sort is based on both the type of subscription purchased and property listing criteria. Criteria include items such as number of photos and reviews that are aimed at simplifying the process of finding your perfect vacation getaway.
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1 2 3 4 5 ....151
  • Viewed

Spectacular Siesta Key Gulf Views. Quiet and Comfortable NonSmoking Condo.

2 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
33 Reviews
#173043

$1,100 - $1,695 week
Accepts Online Payments
  • Viewed

Luxurious Custom-Designed Contemporary Home, a Stone's Throw from the Beach

3 Bedrooms, 4 Bathrooms, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. North Captiva Island Vacation Rentals
19 Reviews
#268650

$1,900 - $3,700 week
  • Viewed

Wow! Updated Penthouse Beachfront Condo, Corner Unit, WiFi, HDTV, Views...

2 Bedrooms, 2 Bathrooms, Sleeps 4
  1. Florida South Central Gulf Coast >
  2. Sanibel Island Vacation Rentals
28 Reviews
#153241

$1,490 - $2,750 week
  • Viewed

Fantastic Water Front Condo, 1st Floor, WiFi, HDTV - Mariner Pointe (951)

1 Bedrooms, 1 Bathroom, Sleeps 4
  1. Florida South Central Gulf Coast >
  2. Sanibel Island Vacation Rentals
21 Reviews
#220118

$825 - $1,425 week
  • Viewed

Waterfront Luxury Family Home, Boat (optional), Heated Pool & Jacuzzi, Fishing

3 Bedrooms, 3 Bathrooms, Sleeps 7
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
5 Reviews
#254128

$200 night
$990 - $1,400 week
$3,450 - $3,799 month
  • Viewed

Spectacular waterfront view. April Availability $2,800 mo Five Star Quality

2 Bedrooms, 2 Bathrooms, Sleeps 4
  1. Anna Maria Island >
  2. Holmes Beach Vacation Rentals
2 Reviews
#270319

$2,999 - $3,600 month
Accepts Online Payments
  • Viewed

Ocean Views, Huge Pool, Putting Green, Luxury at Windswept!

5 Bedrooms, 2 Bathrooms, Sleeps 12
  1. Florida South Central Gulf Coast >
  2. North Captiva Island Vacation Rentals
47 Reviews
#225967

$1,900 - $5,500 week
Special Offer
SUMMER 2012 DEALS (April 28 - June 9)
  • Viewed

Five Star Beachfront Condo, romantic and luxurious

2 Bedrooms, 1 Bathroom, 1 Half Bath, Sleeps 4
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
6 Reviews
#147350

$1,495 - $1,995 week
$4,995 - $6,995 month
  • Viewed

Plantation , Venice Florida Low season special rates

2 Bedrooms, 2 Bathrooms, Sleeps 5
  1. Florida South Central Gulf Coast >
  2. Venice Vacation Rentals
23 Reviews
#150707

$750 week
$2,100 - $3,000 month
  • Viewed

Siesta Key Escape

3 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
9 Reviews
#345147

$1,600 - $2,000 week
$4,500 - $5,000 month
  • Viewed

Charming and Luxury Gulf Acces Pool Home with Speedboat Close to Cape Harbour

3 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
1 Reviews
#272148

$1,650 week
$5,900 month
  • Viewed

South Exposure Luxury Waterfront Home with Pool, Spa and a 27ft Regal boat

3 Bedrooms, 3 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
#954821

$158 - $237 night
$921 - $1,381 week
$3,157 - $4,736 month
  • Viewed

South Facing Luxury Home and Boat on Wide Canal close to Gulf with Amazing Views

4 Bedrooms, 3 Bathrooms, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
#940526

$254 - $381 night
$1,481 - $2,221 week
$5,077 - $7,616 month
  • Viewed

Private Heated Pool - Near the Beach - Get away to the Island this year!

3 Bedrooms, 3 Bathrooms, Sleeps 8
  1. Anna Maria Island >
  2. Holmes Beach Vacation Rentals
4 Reviews
#279164

$1,200 - $2,500 week
$4,600 month
  • Viewed

2,150 Square Foot Gulfside Beachfront Townhouse.

2 Bedrooms, 2 Bathrooms, 1 Half Bath, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
#117853

$1,595 - $2,520 week
  • Viewed

Siesta Key Beach Cottage Directly Across The Street From #1 Beach In The USA

1 Bedrooms, 1 Bathroom, Sleeps 2
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
1 Reviews
#931257

$800 - $1,000 week
$2,600 - $3,400 month
  • Viewed

Island Paradise Beach to Bay

2 Bedrooms, 2 Bathrooms, Sleeps 4
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
2 Reviews
#336652

$900 week
$4,000 month
  • Viewed

Beautiful Luxury Home - Private 80 Foot Floating Yacht Dock-quiet & comfortable

4 Bedrooms, 5 Bathrooms, 1 Half Bath, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. Fort Myers Vacation Rentals
#911715

$3,000 - $6,000 week
$10,000 - $16,000 month
  • Viewed

Modern Newly Renovated waterfront heated pool home

4 Bedrooms, 2 Bathrooms, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
#933010

$775 - $990 week
$2,900 - $3,850 month
  • Viewed

Affordable,family friendly ground floor home with a lush courtyard pool

3 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Sanibel Island Vacation Rentals
#929937

$2,700 - $6,000 month
  • Viewed

True Beachfront,Lux 5 Bedroom,5 Bath, Pool & Tennis,Island's Best Private Beach

5 Bedrooms, 5 Bathrooms, Sleeps 10
  1. Florida South Central Gulf Coast >
  2. North Captiva Island Vacation Rentals
#394262

$4,500 week
  • Viewed

TOP VILLAS - Stylish and Beautiful Harbour Front Vacation Rental

5 Bedrooms, 2 Bathrooms, Sleeps 10
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
11 Reviews
#385888

$528 - $634 night
$3,700 - $4,440 week
$14,800 - $17,760 month
  • Viewed

TOP VILLAS - Ultra Luxury, Cape Coral, 6 Bedroom, 6 Bathroom Mansion

6 Bedrooms, 6 Bathrooms, Sleeps 12
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
#325928

$457 - $548 night
$3,200 - $3,840 week
$12,800 - $15,360 month
  • Viewed

Only Sea Shells unit with a view of the Gulf...3 day stays OK

2 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Sanibel Island Vacation Rentals
10 Reviews
#174695

$185 - $350 night
$695 - $1,750 week
  • Viewed

Stay on the Beach at the Shells Villa

3 Bedrooms, 2 Bathrooms, 1 Half Bath, Sleeps 10
  1. Florida South Central Gulf Coast >
  2. Siesta Key Vacation Rentals
8 Reviews
#228042

$1,250 - $1,900 week
$3,600 - $6,000 month
  • Viewed

April & May '12 Availability - Inquire Now! Sea Shells of Sanibel #39

2 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Sanibel Island Vacation Rentals
19 Reviews
#226665

$160 - $300 night
$595 - $1,650 week
  • Viewed

Paradise Found, Wifi, Close to Fort Myers, Sanibel & Captiva Beache & Airport

3 Bedrooms, 2 Bathrooms, 1 Half Bath, Sleeps 6
  1. Florida South Central Gulf Coast >
  2. Fort Myers Vacation Rentals
9 Reviews
#256016

$700 - $800 week
$1,400 - $3,000 month
  • Viewed

Beachfront on Anna Maria Island-April, May Vacancies

2 Bedrooms, 2 Bathrooms, Sleeps 6
  1. Anna Maria Island >
  2. Bradenton Beach Vacation Rentals
12 Reviews
#263547

$1,150 - $1,500 week
$3,600 - $5,000 month
  • Viewed

Relaxing Near Beach Home with secluded private pool and lots of amenities

3 Bedrooms, 2 Bathrooms, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. Captiva Island Vacation Rentals
4 Reviews
#308819

$2,690 - $3,790 week
  • Viewed

Beautiful Luxury Private Waterside Pool Villa in quite location. Boat access.

4 Bedrooms, 3 Bathrooms, Sleeps 8
  1. Florida South Central Gulf Coast >
  2. Cape Coral Vacation Rentals
20 Reviews
#348923

$850 - $1,250 week
$2,750 - $3,950 month
1 2 3 4 5 ....151
Sort Properties By: 
HomeAway Sort is based on both the type of subscription purchased and property listing criteria. Criteria include items such as number of photos and reviews that are aimed at simplifying the process of finding your perfect vacation getaway.
Compare Selected