Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast: Condos, Houses & More(9,477)

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Private Access to the Beach & 1 Block to the Village
    3 Bedrooms,
  • 2 Bathrooms, 
  • 1 Half Bath
    • , Sleeps 10
$182
per night

Private Access to the Beach & 1 Block to the Village

Book it Now!
2 - 7 night Minimum Stay
  • 3 BR,
  • 2 BA,
  • 1 HF BA,
  • Sleeps 10
  1. Florida South Central Gulf Coast >
  2. Siesta Key Villa
#228042
    (20)
    True Beachfront Beach House on Private Beach
      2 Bedrooms, Sleeps 4
    $1,204 - $1,820
    per week

    True Beachfront Beach House on Private Beach

    Book it Now!
    7 night Minimum Stay
    • 2 BR,
    • Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Manasota Key House
    #308815
      (37)
      Exclusive Waterfront Villa Tropical Breeze, Pool + Spa, WIFI, TIKI Hut, 2 Jetski
        4 Bedrooms,
      • 2 Bathrooms
        • , Sleeps 8
      $128 - $157
      per night

      Exclusive Waterfront Villa Tropical Breeze, Pool + Spa, WIFI, TIKI Hut, 2 Jetski

      Book it Now!
      5 night Minimum Stay
      • 4 BR,
      • 2 BA,
      • Sleeps 8
      1. Florida South Central Gulf Coast >
      2. Cape Coral Villa
      #518306
        (46)
        Luxury Remodeled Beachfront Penthouse with Private Sundeck
          2 Bedrooms,
        • 2 Bathrooms
          • , Sleeps 6
        $1,904 - $3,885
        per week

        Luxury Remodeled Beachfront Penthouse with Private Sundeck

        Book it Now!
        7 night Minimum Stay
        • 2 BR,
        • 2 BA,
        • Sleeps 6
        1. Florida South Central Gulf Coast >
        2. Sanibel Island Condo
        #165420vb
          (9)
          Contemporary Pool Villa - private Beach - heated Pool and Jacuzzi - WiFi!
            3 Bedrooms,
          • 2 Bathrooms
            • , Sleeps 7
          $745 - $1,245
          per week

          Contemporary Pool Villa - private Beach - heated Pool and Jacuzzi - WiFi!

          7 - 28 night Minimum Stay
          • 3 BR,
          • 2 BA,
          • Sleeps 7
          1. Florida South Central Gulf Coast >
          2. Venice House
          #788891
            (14)
            Beachfront Penthouse - Gulf View! 2 BR/BA, WiFi, #1 Beach in the US!
              2 Bedrooms,
            • 2 Bathrooms
              • , Sleeps 6
            $999 - $1,750
            per week

            Beachfront Penthouse - Gulf View! 2 BR/BA, WiFi, #1 Beach in the US!

            Book it Now!
            7 night Minimum Stay
            • 2 BR,
            • 2 BA,
            • Sleeps 6
            1. Florida South Central Gulf Coast >
            2. Siesta Key Condo
            #387889vb
              (11)
              Villa of highest class in southern location, big pool area, direct golf access
                4 Bedrooms,
              • 3 Bathrooms
                • , Sleeps 10
              $165 - $183
              per night

              Villa of highest class in southern location, big pool area, direct golf access

              Book it Now!
              3 night Minimum Stay
              • 4 BR,
              • 3 BA,
              • Sleeps 10
              1. Florida South Central Gulf Coast >
              2. Cape Coral Villa
              #43344
                (17)
                SIESTA KEY - 2BR 2BA - Sorry, July is Gone Next Avail is August
                  2 Bedrooms,
                • 2 Bathrooms
                  • , Sleeps 4
                $865 - $1,275
                per week

                SIESTA KEY - 2BR 2BA - Sorry, July is Gone Next Avail is August

                7 night Minimum Stay
                • 2 BR,
                • 2 BA,
                • Sleeps 4
                1. Florida South Central Gulf Coast >
                2. Siesta Key Condo
                #294616
                  (45)
                  Cape Coral Waterfront Vacation Home/ Remodeled/Low Rates
                    3 Bedrooms,
                  • 3 Bathrooms
                    • , Sleeps 6
                  $245
                  per night

                  Cape Coral Waterfront Vacation Home/ Remodeled/Low Rates

                  2 night Minimum Stay
                  • 3 BR,
                  • 3 BA,
                  • Sleeps 6
                  1. Florida South Central Gulf Coast >
                  2. Cape Coral House
                  #995566
                    (30)
                    One of the Nicest Homes on Captiva Island!
                      3 Bedrooms,
                    • 2 Bathrooms
                      • , Sleeps 6
                    $1,595 - $3,695
                    per week

                    One of the Nicest Homes on Captiva Island!

                    7 night Minimum Stay
                    • 3 BR,
                    • 2 BA,
                    • Sleeps 6
                    1. Florida South Central Gulf Coast >
                    2. Captiva Island House
                    #200223
                      (115)
                      Directly on Siesta Key Beach, 2 Blocks to Village, Ground Floor
                        2 Bedrooms,
                      • 2 Bathrooms
                        • , Sleeps 5
                      $805 - $1,995
                      per week

                      Directly on Siesta Key Beach, 2 Blocks to Village, Ground Floor

                      Book it Now!
                      7 night Minimum Stay
                      • 2 BR,
                      • 2 BA,
                      • Sleeps 5
                      1. Florida South Central Gulf Coast >
                      2. Siesta Key Condo
                      #3024960
                        (8)
                        Turtle Bay Condos * Lemon Bay * Beach * Heated Pool * Boat Dock * Fishing * WiFi
                          2 Bedrooms,
                        • 1 Bathroom
                          • , Sleeps 6
                        $150 - $225
                        per night

                        Turtle Bay Condos * Lemon Bay * Beach * Heated Pool * Boat Dock * Fishing * WiFi

                        2 night Minimum Stay
                        • 2 BR,
                        • 1 BA,
                        • Sleeps 6
                        1. Florida South Central Gulf Coast >
                        2. Manasota Key Condo
                        #182250
                          (70)
                          Beautiful Luxury Private Waterside Pool Villa in quiet location. Boat access.
                            4 Bedrooms,
                          • 3 Bathrooms
                            • , Sleeps 8
                          $840 - $1,225
                          per week

                          Beautiful Luxury Private Waterside Pool Villa in quiet location. Boat access.

                          7 night Minimum Stay
                          • 4 BR,
                          • 3 BA,
                          • Sleeps 8
                          1. Florida South Central Gulf Coast >
                          2. Cape Coral Villa
                          #348923
                            (42)
                            Special Offer 15% off Special Offer on open weeks 2013 (June 1 - December 8)
                            Elegant Beachfront Condo w/pool ! Avail. May 19th - May 25th
                              3 Bedrooms,
                            • 2 Bathrooms
                              • , Sleeps 8
                            $1,900 - $2,800
                            per week

                            Elegant Beachfront Condo w/pool ! Avail. May 19th - May 25th

                            7 night Minimum Stay
                            • 3 BR,
                            • 2 BA,
                            • Sleeps 8
                            1. Anna Maria Island >
                            2. Bradenton Beach Condo
                            #361357
                              (19)
                              Villa with 200 m2 w/pool on freshwater canal and golf course in central location
                                4 Bedrooms,
                              • 3 Bathrooms
                                • , Sleeps 8
                              $120 - $173
                              per night

                              Villa with 200 m2 w/pool on freshwater canal and golf course in central location

                              4 - 7 night Minimum Stay
                              • 4 BR,
                              • 3 BA,
                              • Sleeps 8
                              1. Florida South Central Gulf Coast >
                              2. Cape Coral Villa
                              #776602
                                (15)
                                Nightly (4night Min) Rental At Lovely Sanibel Cottage with Short Walk To Beach
                                  2 Bedrooms, Sleeps 4
                                $164 - $314
                                per night

                                Nightly (4night Min) Rental At Lovely Sanibel Cottage with Short Walk To Beach

                                Book it Now!
                                4 - 6 night Minimum Stay
                                • 2 BR,
                                • Sleeps 4
                                1. Florida South Central Gulf Coast >
                                2. Sanibel Island House
                                #455899vb
                                  (6)
                                  Beautifully Decorated with Great Views and Pool
                                    2 Bedrooms,
                                  • 2 Bathrooms, 
                                  • 1 Half Bath
                                    • , Sleeps 7
                                  $833
                                  per week

                                  Beautifully Decorated with Great Views and Pool

                                  Book it Now!
                                  7 - 31 night Minimum Stay
                                  • 2 BR,
                                  • 2 BA,
                                  • 1 HF BA,
                                  • Sleeps 7
                                  1. Anna Maria Island >
                                  2. Holmes Beach Condo
                                  #187770vb
                                    (6)
                                    Remodeled 3 BR Pool Waterfront Dock !
                                      3 Bedrooms,
                                    • 2 Bathrooms
                                      • , Sleeps 8
                                    $125 - $159
                                    per night

                                    Remodeled 3 BR Pool Waterfront Dock !

                                    Book it Now!
                                    4 night Minimum Stay
                                    • 3 BR,
                                    • 2 BA,
                                    • Sleeps 8
                                    1. Florida South Central Gulf Coast >
                                    2. Port Charlotte House
                                    #392639vb
                                      (5)
                                      Yacht Club- Direct Access, Private Pool, Wifi
                                        3 Bedrooms,
                                      • 2 Bathrooms
                                        • , Sleeps 8
                                      $595 - $847
                                      per week

                                      Yacht Club- Direct Access, Private Pool, Wifi

                                      Book it Now!
                                      7 night Minimum Stay
                                      • 3 BR,
                                      • 2 BA,
                                      • Sleeps 8
                                      1. Florida South Central Gulf Coast >
                                      2. Cape Coral House
                                      #404023vb
                                        (5)
                                        25 Steps to sand GULF FRONT CONDO Private, Quiet, 1st floor
                                          2 Bedrooms,
                                        • 2 Bathrooms
                                          • , Sleeps 4
                                        $1,400 - $1,750
                                        per week

                                        25 Steps to sand GULF FRONT CONDO Private, Quiet, 1st floor

                                        Book it Now!
                                        7 night Minimum Stay
                                        • 2 BR,
                                        • 2 BA,
                                        • Sleeps 4
                                        1. Anna Maria Island >
                                        2. Holmes Beach Condo
                                        #307642
                                          (4)
                                          All new Waterfront Condo, Wifi, HDTV, Pool, Tennis, Fishing Pier
                                            2 Bedrooms,
                                          • 2 Bathrooms
                                            • , Sleeps 4
                                          $130
                                          per night

                                          All new Waterfront Condo, Wifi, HDTV, Pool, Tennis, Fishing Pier

                                          Book it Now!
                                          1 - 7 night Minimum Stay
                                          • 2 BR,
                                          • 2 BA,
                                          • Sleeps 4
                                          1. Florida South Central Gulf Coast >
                                          2. Sanibel Island Condo
                                          #434717vb
                                            (5)
                                            Waterfront,Eletric Heated Pool,Wifi,over 2100 sq ft
                                              3 Bedrooms,
                                            • 2 Bathrooms
                                              • , Sleeps 6
                                            $688 - $889
                                            per week

                                            Waterfront,Eletric Heated Pool,Wifi,over 2100 sq ft

                                            Book it Now!
                                            7 night Minimum Stay
                                            • 3 BR,
                                            • 2 BA,
                                            • Sleeps 6
                                            1. Florida South Central Gulf Coast >
                                            2. Cape Coral Villa
                                            #3471265
                                              (5)
                                              Beachfront! Spectacular Sunset Dining! Only 3 weeks Left for Nov./Dec. Special!
                                                4 Bedrooms,
                                              • 4 Bathrooms
                                                • , Sleeps 11
                                              $3,003 - $7,504
                                              per week

                                              Beachfront! Spectacular Sunset Dining! Only 3 weeks Left for Nov./Dec. Special!

                                              7 night Minimum Stay
                                              • 4 BR,
                                              • 4 BA,
                                              • Sleeps 11
                                              1. Florida South Central Gulf Coast >
                                              2. Captiva Island House
                                              #92300vb
                                                54 Reviews
                                                Villa Lakeview on Herons Watch only 2 Miles to the beaches of AMI
                                                  3 Bedrooms,
                                                • 2 Bathrooms
                                                  • , Sleeps 6
                                                $1,204
                                                per week

                                                Villa Lakeview on Herons Watch only 2 Miles to the beaches of AMI

                                                7 night Minimum Stay
                                                • 3 BR,
                                                • 2 BA,
                                                • Sleeps 6
                                                1. Anna Maria Island >
                                                2. Bradenton Beach House
                                                #3021153
                                                  (13)
                                                  Walk to the Beach - Vintage Charm Bungalow on Longboat Key
                                                    3 Bedrooms,
                                                  • 2 Bathrooms
                                                    • , Sleeps 6
                                                  $185 - $200
                                                  per night

                                                  Walk to the Beach - Vintage Charm Bungalow on Longboat Key

                                                  Book it Now!
                                                  3 - 4 night Minimum Stay
                                                  • 3 BR,
                                                  • 2 BA,
                                                  • Sleeps 6
                                                  1. Florida South Central Gulf Coast >
                                                  2. Longboat Key House
                                                  #414104vb
                                                    (4)
                                                    Fine Living Relaxation and Enjoyment! Enjoy Pool, Beach and Sunsets
                                                      3 Bedrooms,
                                                    • 2 Bathrooms, 
                                                    • 1 Half Bath
                                                      • , Sleeps 12
                                                    $286 - $400
                                                    per night

                                                    Fine Living Relaxation and Enjoyment! Enjoy Pool, Beach and Sunsets

                                                    Book it Now!
                                                    3 - 5 night Minimum Stay
                                                    • 3 BR,
                                                    • 2 BA,
                                                    • 1 HF BA,
                                                    • Sleeps 12
                                                    1. Florida South Central Gulf Coast >
                                                    2. Longboat Key House
                                                    #447571vb
                                                      (4)
                                                      Look at our New HD Video!
                                                        3 Bedrooms,
                                                      • 2 Bathrooms, 
                                                      • 1 Half Bath
                                                        • , Sleeps 10

                                                      Look at our New HD Video!

                                                      • 3 BR,
                                                      • 2 BA,
                                                      • 1 HF BA,
                                                      • Sleeps 10
                                                      1. Florida South Central Gulf Coast >
                                                      2. Siesta Key Condo
                                                      #382819vb
                                                        (24)
                                                        New Luxury home, pool, 600ft from sandy gulf beach
                                                          3 Bedrooms,
                                                        • 2 Bathrooms, 
                                                        • 1 Half Bath
                                                          • , Sleeps 8
                                                        $1,610 - $2,450
                                                        per week

                                                        New Luxury home, pool, 600ft from sandy gulf beach

                                                        7 night Minimum Stay
                                                        • 3 BR,
                                                        • 2 BA,
                                                        • 1 HF BA,
                                                        • Sleeps 8
                                                        1. Anna Maria Island >
                                                        2. Holmes Beach House
                                                        #179538
                                                          (10)
                                                          2 BR Heated Pool Waterfront with Dock, Remodeled 2012
                                                            2 Bedrooms,
                                                          • 2 Bathrooms
                                                            • , Sleeps 6
                                                          $99 - $139
                                                          per night

                                                          2 BR Heated Pool Waterfront with Dock, Remodeled 2012

                                                          Book it Now!
                                                          3 night Minimum Stay
                                                          • 2 BR,
                                                          • 2 BA,
                                                          • Sleeps 6
                                                          1. Florida South Central Gulf Coast >
                                                          2. Port Charlotte House
                                                          #392651vb
                                                            2 Reviews
                                                            Clean Spacious 2 BR Condo at Siesta Beach - Walk to Village!
                                                              2 Bedrooms, Sleeps 6
                                                            $860 - $1,464
                                                            per week

                                                            Clean Spacious 2 BR Condo at Siesta Beach - Walk to Village!

                                                            7 night Minimum Stay
                                                            • 2 BR,
                                                            • Sleeps 6
                                                            1. Florida South Central Gulf Coast >
                                                            2. Siesta Key Condo
                                                            #970874
                                                              (13)
                                                              • 1 - 30 of 9,477
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