Make a Florida vacation rental your home away from home in Florida's South Central Gulf region.

Step out the door of your Sanibel Island vacation rental and you’ll be on one of Florida's best shelling beaches. Discover the charm of Fort Myers vacation rentals, which offer easy access to dozens of golf courses and lovely beaches.

A of Sarasota vacation rental makes a great home base for enjoying the city's lively arts scene. Guests of Anna Maria Island vacation rentals can enjoy a seven-mile long beach.

You're sure to find the perfect condo rental or beachfront cottage in Florida's South Central Gulf region. Reserve your Florida vacation rental today!

Expand your search for Florida vacation rentals to include Longboat Key condos, Miami vacation rentals and Ft. Lauderdale rentals in South Florida, Destin vacation rentals and Sanibel Island rentals on the Gulf Coast, Bradenton Beach rentals, or Orlando vacation home rentals near Disney.

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Florida South Central Gulf Coast Rentals: Condos, Villa, Homes & More(4,488)

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1 2 3 4 5 ....150
  • Viewed

Wow! Updated Penthouse Beachfront Condo, Corner Unit, WiFi, HDTV, Views...

2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Sanibel Island Vacation Rentals
    28 Reviews
    #153241

    $1,490 - $2,475 week
    • Viewed

    Fantastic Water Front Condo, 1st Floor, WiFi, HDTV - Mariner Pointe (951)

    1 Bedrooms,
  • 1 Bathroom
    • , Sleeps 2
    1. Florida South Central Gulf Coast >
    2. Sanibel Island Vacation Rentals
    22 Reviews
    #220118

    $825 - $1,425 week
    Special Offer
    ** Summer 2012 Construction Special ** (May 5 - August 31)
    • Viewed

    Luxurious Custom-Designed Contemporary Home, a Stone's Throw from the Beach

    3 Bedrooms,
  • 4 Bathrooms
    • , Sleeps 8
    1. Florida South Central Gulf Coast >
    2. North Captiva Island Vacation Rentals
    23 Reviews
    #268650

    $1,900 - $3,700 week
    Accepts Online Payments
    • Viewed

    Spectacular Siesta Key Gulf Views. Quiet and Comfortable NonSmoking Condo.

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    33 Reviews
    #173043

    $1,295 - $1,790 week
    Accepts Online Payments
    • Viewed

    Ocean Views, Huge Pool, Putting Green, Luxury at Windswept!

    5 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 12
    1. Florida South Central Gulf Coast >
    2. North Captiva Island Vacation Rentals
    48 Reviews
    #225967

    $1,927 - $5,900 week
    Accepts Online Payments
    Special Offer
    WOW! This is it! You Found Your Deal! (April 16 - June 4)
    • Viewed

    Luxury 2-Bedrooms Beachfront Sundial on Gulf of Mexico

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Sanibel Island Vacation Rentals
    16 Reviews
    #200967

    $1,485 - $2,895 week
    • Viewed

    Beachfront on Gulf of Mexico Now Booking Summer Weeks

    1 Bedrooms,
  • 1 Bathroom
    • , Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Sanibel Island Vacation Rentals
    12 Reviews
    #200605

    $1,010 - $2,010 week
    • Viewed

    Five Star Beachfront Condo, romantic and luxurious

    2 Bedrooms,
  • 1 Bathroom
  • , 1 Half Bath
    • , Sleeps 5
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    8 Reviews
    #147350

    $1,495 - $1,995 week
    $4,995 - $6,995 month
    Special Offer
    10% off the weeks of 8/25,9/1,9/15,9/22 (August 18 - September 29)
    • Viewed

    Tropical Breeze a Luxury Home - 60 Yards from a Fantastic Beach

    5 Bedrooms,
  • 5 Bathrooms
    • , Sleeps 10
    1. Florida South Central Gulf Coast >
    2. Captiva Island Vacation Rentals
    54 Reviews
    #309324

    $6,665 - $6,900 week
    • Viewed

    'Seawatch' on the beach at North Captiva Island

    4 Bedrooms,
  • 2 Bathrooms
  • , 1 Half Bath
    • , Sleeps 12
    1. Florida South Central Gulf Coast >
    2. North Captiva Island Vacation Rentals
    19 Reviews
    #164483

    $1,750 - $3,200 week
    Accepts Online Payments
    • Viewed

    Siesta Key Beach Cottage Directly Across The Street From #1 Beach In The USA

    1 Bedrooms,
  • 1 Bathroom
    • , Sleeps 2
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    5 Reviews
    #931257

    $800 - $1,000 week
    $2,600 - $3,400 month
    Accepts Online Payments
    • Viewed

    Siesta Key Escape

    3 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    10 Reviews
    #345147

    $1,600 - $2,000 week
    $4,500 - $5,000 month
    • Viewed

    South Facing Luxury Home and Boat on Wide Canal close to Gulf with Amazing Views

    4 Bedrooms,
  • 3 Bathrooms
    • , Sleeps 8
    1. Florida South Central Gulf Coast >
    2. Cape Coral Vacation Rentals
    6 Reviews
    #940526

    $254 - $381 night
    $1,481 - $2,221 week
    $5,077 - $7,616 month
    • Viewed

    Charming and Luxury Gulf Acces Pool Home with Speedboat Close to Cape Harbour

    3 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Cape Coral Vacation Rentals
    1 Reviews
    #272148

    No rental rates available - please contact the owner
    • Viewed

    Island Paradise Beach to Bay

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    2 Reviews
    #336652

    $900 week
    • Viewed

    Waterfront Luxury Family Home, Boat (optional), Heated Pool & Jacuzzi, Fishing

    3 Bedrooms,
  • 3 Bathrooms
    • , Sleeps 8
    1. Florida South Central Gulf Coast >
    2. Cape Coral Vacation Rentals
    5 Reviews
    #254128

    $999 - $1,299 week
    $3,499 - $4,199 month
    • Viewed

    South Exposure Luxury Waterfront Home with Pool, Spa and a 27ft Regal boat

    3 Bedrooms,
  • 3 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Cape Coral Vacation Rentals
    2 Reviews
    #954821

    $158 - $237 night
    $921 - $1,381 week
    $3,157 - $4,736 month
    • Viewed

    Overlooking the entire south end of the Island/FREE bikes & kayaks/ Great Value!

    2 Bedrooms, Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Manasota Key Vacation Rentals
    9 Reviews
    #232898

    No rental rates available - please contact the owner
    • Viewed

    2,150 Square Foot Gulfside Beachfront Townhouse.

    2 Bedrooms,
  • 2 Bathrooms
  • , 1 Half Bath
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    #117853

    $1,595 week
    • Viewed

    Siesta Key Beach #1 in USA steps to Banyan Tree Beach Resort 'Key West' unit

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Siesta Key Vacation Rentals
    #218253

    $175 - $210 night
    $875 - $1,323 week
    $3,325 - $5,027 month
    • Viewed

    Beautiful Luxury Home - Private 80 Foot Floating Yacht Dock-quiet & comfortable

    4 Bedrooms,
  • 5 Bathrooms
  • , 1 Half Bath
    • , Sleeps 8
    1. Florida South Central Gulf Coast >
    2. Fort Myers Vacation Rentals
    #911715

    $3,000 - $6,000 week
    $10,000 - $16,000 month
    • Viewed

    Private Heated Pool - Near the Beach - Get away to the Island this year!

    3 Bedrooms,
  • 3 Bathrooms
    • , Sleeps 8
    1. Anna Maria Island >
    2. Holmes Beach Vacation Rentals
    4 Reviews
    #279164

    $1,200 - $2,500 week
    • Viewed

    Island Dream-Luxury Tropical Villa with Pool and View of Skyway Bridge

    4 Bedrooms,
  • 3 Bathrooms
  • , 1 Half Bath
    • , Sleeps 10
    1. Anna Maria Island >
    2. Anna Maria Vacation Rentals
    #911305

    No rental rates available - please contact the owner
    • Viewed

    LUXURY GULF VIEWS WITH WATERFALL POOL,STEPS TO GORGEOUS GULF BEACHES

    2 Bedrooms,
  • 1 Half Bath
    • , Sleeps 6
    1. Anna Maria Island >
    2. Holmes Beach Vacation Rentals
    2 Reviews
    #973837

    $1,280 week
    • Viewed

    Modern Newly Renovated waterfront heated pool home

    4 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 8
    1. Florida South Central Gulf Coast >
    2. Cape Coral Vacation Rentals
    #933010

    $775 - $850 week
    $2,900 - $3,200 month
    • Viewed

    Affordable,family friendly ground floor home with a lush courtyard pool

    3 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Sanibel Island Vacation Rentals
    #929937

    $2,700 month
    • Viewed

    True Beachfront,Lux 5 Bedroom,5 Bath, Pool & Tennis,Island's Best Private Beach

    5 Bedrooms,
  • 5 Bathrooms
    • , Sleeps 10
    1. Florida South Central Gulf Coast >
    2. North Captiva Island Vacation Rentals
    #394262

    No rental rates available - please contact the owner
    • Viewed

    #208 Beach property, Family Friendly, Beautiful updated condo, Heated pool

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 6
    1. Florida South Central Gulf Coast >
    2. Longboat Key Vacation Rentals
    62 Reviews
    #240486

    $163 - $189 night
    $1,140 - $1,324 week
    Accepts Online Payments
    • Viewed

    Tropical Beach Bungalow; Your Own Private Paradise in the Middle of Everything

    2 Bedrooms,
  • 2 Bathrooms
    • , Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Fort Myers Vacation Rentals
    17 Reviews
    #242601

    $895 - $1,695 week
    $5,495 - $5,795 month
    Accepts Online Payments
    • Viewed

    Cleanest, Cutest and Most Convenient Condo on Fort Myers Beach

    1 Bedrooms,
  • 1 Bathroom
    • , Sleeps 4
    1. Florida South Central Gulf Coast >
    2. Fort Myers Beach Vacation Rentals
    7 Reviews
    #335284

    $525 - $875 week
    Accepts Online Payments
    1 2 3 4 5 ....150
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