I came across La Sienna on homeaway.com 5 years ago and have never gone anywhere else since. My original plans had been to stay in every neighbourhood on Manhattan until I'd seen them all but in La Sienna, I found my home away from home.
Yvette, the owner and resident jack of all trades, is an amazing host.
This is a safe, quiet, spotlessly-clean, affordable place to stay. I travel by myself and come to New York at least once a year and I have never hesitated to recommend La Sienna to anyone that is planning a visit to New York.