We were married in Muir Woods on this trip and spent half the time on a "mini-honeymoon" here. We were originally looking to stay in Marina, Pacific Heights, etc., but saw this and decided to try off the beaten tourist path instead. This was indeed a memorable place. The views are spectacular (being high on a hill), the house is spacious and very elegant, and it really makes you feel like you're living in the city rather than just being a tourist. I've stayed at many good VRBO properties but this one is at the top.
A Whole Foods is conveniently located nearby. We had a car but had no trouble parking the whole time. The neighborhood is very quiet and friendly, with a lot of small restaurants and cafes nearby. It's definitely worth checking out this part of the city!